We used single-particle electron microscopy to characterize the structure and subunit organization of the Mediator Head module that controls Mediator–RNA polymerase II (RNAPII) and Mediator-promoter ...
The Polycomb group of epigenetic enzymes represses expression of developmentally regulated genes in many eukaryotes. This group includes the Polycomb repressive complex 1 (PRC1), which ubiquitylates ...
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